
Chemotherapy is the use of drugs for treating cancer. The drugs can be swallowed in pill form or they can be injected by a needle into a vein or muscle. Chemotherapy is systemic therapy. This means that the drug enters the bloodstream and circulates throughout the body (through the whole system) to reach and destroy the cancer cells.In treating mesothelioma, these drugs may also be given intrapleurally (directly into the chest cavity), or intraperitoneally (into the abdominal cavity). Depending on the type and stage of mesothelioma, chemotherapy may be given as the primary (main) treatment or as an adjuvant (addition) to surgery.Several anticancer drugs have been used to treat mesothelioma. The drug most effective when given alone is doxorubicin (Adriamycin). Other drugs that may be given alone include cisplatin and methotrexate. These anticancer drugs are often given in combination to try to increase their effectiveness. Combinations of drugs used in the treatment of mesothelioma include methotrexate and vincristine; cisplatin and alimta, vinblastine and mitomycin; cisplatin and doxorubicin; and doxorubicin, cyclophosphamide (or ifosfamide) and cisplatin. Other drugs such as paclitaxel and irinotecan are currently being studied to determine their effectiveness in treating mesothelioma.Chemotherapy drugs kill cancer cells but also damage some normal cells. Therefore, careful attention must be given to avoiding or minimizing side effects, which depend on the specific drugs, the amount taken, and the length of treatment. Temporary side effects might include nausea and vomiting, loss of appetite, loss of hair, and mouth sores. Because chemotherapy can damage the blood-producing cells of the bone marrow, patients may have low blood cell counts. This can result in an increased risk of infection (due to a shortage of white blood cells), bleeding or bruising after minor cuts or injuries (due to a shortage of blood platelets), and fatigue or shortness of breath (due to low red blood cell counts).Most side effects disappear once treatment is stopped. There are remedies for many of the temporary side effects of chemotherapy. For example, antiemetic drugs can be given to prevent or reduce nausea and vomiting. If you experience any side effects, be sure to talk with your doctor.
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Malignant pleural mesothelioma in pregnancyA 37-year-old pregnant woman presented at 18 weeks' gestation with unrelenting chest and shoulder pain, massive pleural effusion, and a large thoracic mass. Biopsy revealed an undifferentiated sarcomatous pleural mesothelioma. malignant mesothelioma is a rare thoracic malignancy, which has not been described in pregnancy and appears to be minimally affected by the pregnant state.PMID: 11243299 [PubMed - indexed for MEDLINE] Click here to order or save article
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Wednesday, April 15, 2009
Surgery and DiagnosisThe diagnosis of malignant pleural Mesothelioma is made most firmly by the inspection of a biopsy of the pleura under the microscope. A diagnosis confirmed by biopsy helps when planning further treatment, for some treatments it is essential and it also verifies claims for compensation. It may be possible to obtain a reliable biopsy either by the removal of fluid from the chest (pleural fluid cytology) or a needle biopsy whereby a biopsy is obtained under local anaesthetic sometimes guided by a CT or ultra sound scanner. However, particularly in the early stages, negative results by these tests do not rule out the possibility of Mesothelioma. It may be felt that a surgical biopsy is warranted.There are two “keyhole” procedures that can be used. Under a local anaesthetic it is possible to have a medical thoracoscopy. This involves a small camera telescope being introduced through a single 1-2 cm cut from which a biopsy can be taken. If a general anaesthetic is performed, a thoracic surgeon may perform Video Assisted Thoracoscopic Surgery (VATS), through between 1 and 3 such cuts. This allows a larger biopsy to be performed and a full assessment of the pleura to be made. Picture Source - www.thoracicgroup.com
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SurgerySurgery can have an important role within the treatment of malignant Mesothelioma in confirming the diagnosis, assessing the spread of the tumour (stage) and in the control of symptoms.All terms in bold in this section can be found in the Glossary.Picture Source - www.mayoclinic.org
How dangerous is it?Your close relative — perhaps even you yourself — has been diagnosed with mesothelioma, a form of cancer newly affecting 2,000 to 3,000 individuals in the United States each year. A thousand questions run through your mind: What is mesothelioma?How dangerous is it?How long has my relative got to live?How will this development impact my relative’s family?How did my relative contract mesothelioma?What kinds of medical treatments are available? How successful have they proven?Are there any nonmedical alternatives?What have others done in this situation? What can I do?What choices do I have?Is there any hope?Who can help?
Does anyone care?
Mesothelioma Legal Information Center
Posted by mudasir